I use an n52 for all my games, well apart from those that are mouse driven like EVE, I tend to use a standard FPS layout.

WASD (3,7,8,9) as the main movement keys; 1 & 2 for targeting; 6 is shift; 11 is control; 12 is alt; 13 is x (down in flight/swimming). My button bars (I use trinity) are the thumb-pad (1-4); big thumb button 5; Orange Button is 6; then the remainder 7-10 are buttons 4,5,10,14. I also have delete mapped to the button under the scroll wheel.

I don't use any other shift states, and I still have access to forty buttons with one hand. In fact even on my seventy I only use about 20-30 buttons.

While I have two n52s I have never managed to get both working together on the same machine (I have used an n50 and an n52 together), but when I used two machines I used both and my follower's n52 was setup so I had a control set, plus when I used a shift state to move all the button keys onto the main pad (buttons 1-10) with ctrl and alt mapped to 11 and 12, again giving good control... Now I just us one PC and keyclone which works 100% better.