Macro's I do a whole bunch of ways........

ALT 1-4 to set each toons focus to party1target and set a raid target icon.

CTRL 1-5 (poly/poly/fear/shackle/banishseducevoidy) to set focus to party1 target if no focus already AND cast the CC spell.

I also have all the CC spells on the shift keys per toon (on the same key as the CTRL version, except my shift combos are not broadcast) and use them directly like in the 2nd boss in ramparts.

and then I have 1 key to cast all CC spells.

@ Electrissy
I don't play with 2 mice. Obviously you can use software to mouse share.