Depending how you set up your assists.. this can be relatively easy.

Do a forum search for the "No Focus Manifesto".
If one of your groups has Toon A, B, C, D, and E as their target groups.
And the other group has F, G, H, I, and J, as their target groups.
Your big button then would have each group follow their appropriate leader.
You could even go with a combo big button, for controlling all 10.