While I'm waiting on my new rig to arrive I thought I'd try to get some opinions on what's best for performance for Multiboxing (I pland on running 5toons) on one PC (Specs at bottom of post) before I load WoW and other related software to my rig. I've done some searching and have seen varried opinions on what's best for the following:

1. Is it better to have WoW and all it's related software on a different HD than your operating system? I am assuming it is. (Yes or NO?)

2. Is it better to use one WoW folder or Multiple? If multiple WoW folders are used does symlinking increase performance?

3. Is it better to split up the WoWs across multiple cores of the CPU through manual settings, or does it basically do the same thing when you assign them through Keyclone or ISBoxer if it has that option?

Thanks in advance for the help and advice.

PC Details:
-i7 CPU
-ASUS P6T Deluxe V2 mobo
-12gig RAM
-GTX 280 1MB video card
-2x 500MB HD
-1000W PS
-Liquid Cooled
-Vista Home Premium 64-bit
-Currently using Keyclone, but thinking about using IS and ISBoxer