howdy laaglander and welcome to the forums!

thee are basically 3 levels of wow macro setup.

1. /follow and /assist ... the simplest to set up, doesn't allow for leader change
2. focus based macros... takes a bit more to set up, but allows for leader change. you lose the ability to use /focus
3. FTL ... definitely a lot more to set up. allows for leader change. /focus is available

beyond that, for general setup, keyclone gives you the do-not-pass list, round-robin, mouse-maps, keymaps, and the maximizer (which does the cool layouts)

if you have any questions, please feel free to drop me a note.

have a great night,

Rob