1. Make sure to check your macro book and make sure the spelling of all words are correct. (something i add a random letter to the spell name by accident, but happens often when fiddling with macros)

2. Make sure both characters are in the same party

3. Make sure the target you are assisting is indeed the leader of the group, you can't assist yourself w/o a target.

4. Make sure the key press is actually going across (pressing E on one windows presses E on the other).

5. Reset your keybindings if all else fails, then remap, and make sure the keys aren't assigned to 2 things.