IS will see the hardware keypress and work off of that if you prgram that key to do something with IS/ISboxer. You can still use the macroworks software and as long as you don't have that keycombo set up in a keymap it will pass to your active window. You can also enter that key combo into your keymap and have it sent to whichever windows you want, or don't want, by having the same combo as input and output of the keymap.