After experimenting with a lot of configurations w/keyclone(v1.9g) I think I've found a setting that works really well.
Using the 24" monitor as the main monitor and the (2) 20" monitor's on either side placed in portrait mode I was able to utilize the pip/swap feature.

24", region1[F1] = 1920x1200, landscape
Left side 20", region 2[F2] {1200x800, upper portion}, region 4[F4] {1200x800, lower portion}
Right side 20", region 3[F3] {1200x800, upper portion}, region 5[F5] {1200x800, lower portion}

So far so good :thumbup: ...... using Windows 7 (64 bit) Evaluation copy, quad core 2.66Mhz, 8gig ram, (2) 260 GTX video cards