Use the /click method (search the forum and you'll find more information).

Basically you have one button on your toolbar that takes care of all your targeting. The macro is something like this:

/assist [mod:rctrl]Curiously, [mod:lshift]Strong, [mod:ralt]Owltoid


Then all your other macros just have something like the following:
/click Button123 (sorry, don't have the syntax in front of me)
/cast Lightning Bolt