You can achive something like 'VirtualButtons' with HKN (for the checking which region is clicked and broadcating).
But HKN has no ability to draw 'overlays' so for this you might want to use something like kgPanel in WoW.

A quite good explanation how the above could be achived can be found here:
http://www.hotkeynet.com/phpBB3/view...php?f=8&t=1075