Here's mine in action. The space at the bottom is filled with 3 account regions sized down with Keyclone. I have those three set to always be on top.





Here's another shot with Task manager open and the other three accounts at the bottom out of combat. I keep my main window in focus, then take the mouse and move it over the middle of the bottom three in an M shape movement to center the mouse/cursor for those windows either on me, or near my location for Click-on-ground AoE spells.



I keep just about all my spells with cooldowns 1 minute or more on the same key across all accounts and have those keys on roundrobin. Lay of Hand for my pallies all have their own macro which has /target focus /cast Lay of Hands and the Hammer of just has /assist focus /cast Hammer of Justice and so on.

Chat pane on the left is the General pane. The one on the right is Party/Guild pane.