There is another very important difference between "/assist focus" and /cast [target=focustarget]" type macros. Consider the following two macros:
Macro 1:
Code:
/assist focus
/castsequence reset=combat/target/5 insect swarm, moonfire, starfire, starfire, starfire, starfire
Macro2:
Code:
/castsequence [target=focustarget] reset=combat/target/5 insect swarm, moonfire, starfire, starfire, starfire, starfire
Pop Quiz: Which of the above two macros actually works as intended?
Answer: Macro 1.
So, if you prefer to have your macros reset to the beginning of a lengthy castsequence when switching targets, the only one that works is the /assist focus type macro. I'm sure some folks will find creative ways to work around this.

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