I've noticed this problem too when I was trying to grind Stockades. I haven't tried on my alts, only my main. I can't right-click the portraits for the drop-down menu and I can't change my tracking options on my minimap. I'm thinking there is an issue with one of the other addons and not Keyclone as Rob is suggesting. I'm thinking it may be X-Perl or Sexymap. I run Sexymap on all toons, but X-Perl is only on my main. There could have been a coding issue with an update on one of these. I have still not found out how to fix this.