The difference now is, you can use the Pestilence Glyph, and only do Icy Touch and Plague strike once for a longer rotation of using Obliterate and such, since HB is dead for 5 box Dks.

Also, depending on your spec, you can get the frost talent that keeps Obliterate from consuming IT/PS and that makes for an even more complex rotation.
Also, go with Reaping in the Unholy tee, and you get Death Runes when you use Pestilence and Blood Strike so.. It's all up to you.

Something like:

Start off the rotation<>
/use Trinket
/use Trinket
/castsequence reset=target Icy Touch, Plague Strike, Pestilence, Blood Boil, Obliterate, Obliterate, Pestilence, Blood Boil, Obliterate... and so forth.
/cast !Rune Strike
/cast !Blood Tap

I did a lot of testing for many hours with different specs. The one I think I have on my main now is the best I could get so far, and the macros I already forgot, been a little while since I last played, but I think the above is close to what it looks like, also, with the new patch, we got a nice little buff to Death Strike, so, you can sub an Obliterate or two with a Death Strike.

(1)Frost, (2)Unholy, Blood, Blood, Frost/Unholy, (1)(2) Frost/Unholy, Blood, Blood, Frost/Unholy.

It's kind of hard to explain, but it loops back around it self because of the Death Rune Master. But with a bit of tweaking, it becomes a powerful macro.