to sum up... Its useful for everything really I use F for Assist, Shift+F for Follow and Z for 'Interact with target'. And with click to move on Assist>Interact and it runs over, loots, opens NPC screens. Not really automation as such as abusing blizzard rules because it's click-to-move. I find myself spamming Z-('Interact with Target') a lot when using melee characters so he's always facing the mob and within range.