Choose your Path Wisely

There are a number of options for playing EVE Online, you could be a doughty miner, an empire building industrialist, a faithful mission runner, a loyal faction pilot, the defender of your patch of deep space, or a vicious pirate. It can take a long time to reach some goals so you should read around and decide what you'd like to do. As a multiboxer you have an advantage in being able too pursue several goals at once. Specialisation is the key to rapidly gettign to where you want to be, avoid training for one goal and then switching to another, you won't waste time but you won't get as far ahead as you could have done otherwise.

Going Epic for Phat Lewt

The epic mission arc seems to be available to all new players as a matter of course and it gives much better rewards than the other missions you can do when you're starting out so I suggest going through it. Here's a guide here thats pretty good:

http://keithneilson.co.uk/eve-epic-mission-arc-part-1/

Scams, Griefing, Ganking, and Suicide Attacks!

If you come from a WoW background you are probably used to a decent level of customer service and a company that tries to make your play time fun without being overly griefed by other players.

This is not how EVE works! EVE is the opposite to WoW! EVE encourages griefing, scams, ganking, unfair PVP, suicide bombing, all manner of ridiculously unpleasant behaviour by players. Not to mention the worst 'death penalty' of any MMO. If you mention any of this on the EVE forums you will be roundly derided with cries of 'Go back to WoW carebear!', 'LRN2PLAY', etc, etc.

So, you've been warned, in EVE, always assume someone else is out to screw you.

Typical scams include the 'I stole 9 billion from Band of Brothers and I'll give you 10x what you send me' classic