Can't say I've heard of anyone having that sort of problem. Are you sure you didn't hit Shift+Alt+M (which can disable key maps) or some such?
One thing to check is if something broke in ISBoxer while you were playing. If you hit ` (by default, or if you dont have ` try F12) in game then an IS window will come up with some debugging info. It's possible that the key map script crashed and destroyed all of the key mappings in the process (only reason I can think of that you'd see the described behavior). If it did, there should be information pointing to the line of code causing the problem. Otherwise, there is other basic information that might be useful. If you see anything like that, something that looks like an error, etc let me know what it says
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