I use it on windows 7 64-bit with no problems(as long as it is run as administrator), so I see no reason why it will not work on windows vista 64-bit
I am not sure if it has an option to save different settings. I do however export my team to a file on my hard drive after I finish making a setup or configuring a setup. This way all I have to do is load isboxer, load my saved profile, export to innerspace and load profile from innerspace
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