1. No, you do not necessarily need to. However, if it makes it easier for you at some point, then by all means do it. The drawback is that you need to run ISBoxer, open the other profile, and Export, in order to switch Character Sets. ISBoxer is designed to let you keep everything in the same profile. I have like 20 different Sets in mine

2. Unless you're asking about really common groupings like "5 shamans" it might be hard to find the kind of examples that will benefit you most. I was working briefly on describing my configuration and gameplay style on this page though, and that could perhaps give you an idea or two. Otherwise, yeah start a new thread and describe the team you're creating and the mappings you're planning or whatnot, and I'm sure someone will have comments or suggestions