If you are talking about having KeyClone generate a UI Mod that generates and makes available macros which can then be bound directly to hotkeys I'd say it's a great idea, ISBoxer has it and I'm utilizing it for many of my more mundane macro's such as mounting/dismounting/jamba follows, etc.

If you are talking about having KeyClone send a series of keystrokes starting with a / such as a recorded macro from G15 then I'd say it's a waste of time, much like the aformentioned mouse.