Wanted to say thanks to those who gave advice. I've kind of split the difference on team composition. I swapped out two character classes for new toons:

Slot 1) SK
Slot 2) Necromancer
Slot 3) Defiler
Slot 4) Coercer (swapped out the Inquisitor. I may regret the loss in heals later, but I'm hoping the CC makes up for it, and dual healing from one keyboard was proving inefficient - i.e. I was dead by the time the extra heals would have helped or I simul casted both healers and wasted mana 95% of the time)
Slot 5) Warlock (So far the necro mentored down is outparsing her severely, but I think that will change when the group's levels even out)
Slot 6) Troubador (swapped out the Dirge)

We'll see how it goes.

So far I've got everything mapped out nicely to where I can run any toon and manage combat (with the tank pulling aggro as long as the puller survives the initial pull).

I've got something funky going on with my group target macro that I can't figure out. Each character has Ctril 1-6 set as a macro to follow character 1-6. I've set ISBoxer to use F1 through F6 to send the Ctrl-1 - Ctril-6 to each character but the one in the main window. The idea is that I can use the same key and get all the characters pointed at the right toon as opposed to the normal F1-6 behavior which is dependant on group order.

I've verified all the keys and mappings, but when certain characters use the command others end up targetting the wrong toon.

Ugh... So close.. But I'll get it figured out.

Thanks again, all.