my method are similar to Wolpak
using only 1 macro for all toon

macro :
/focus [@mouseover]

addon : Pitbull unit frames
the pitbull ui addon are so i can set all the group alphabetically

HotKeyNet
set one of your key (the key bind to the macro above) to broadcast by region
**mine set on F8**
<Hotkey F8>
<If MouseIsOverWindowRect WoW1 0 0 250 550>
<SendLabel w1, w2, w3, w4, w5>
<Clickmouse Noclick>
<Key F8>
<RestoreMousePos>

<Else If MouseIsOverWindowRect WoW2 0 0 250 550>
<SendLabel w1, w2, w3, w4, w5>
<Clickmouse Noclick>
<Key F8>
<RestoreMousePos>

<Else If MouseIsOverWindowRect WoW3 0 0 250 550>
<SendLabel w1, w2, w3, w4, w5>
<Clickmouse Noclick>
<Key F8>
<RestoreMousePos>

<Else If MouseIsOverWindowRect WoW4 0 0 250 550>
<SendLabel w1, w2, w3, w4, w5>
<Clickmouse Noclick>
<Key F8>
<RestoreMousePos>

<Else If MouseIsOverWindowRect WoW5 0 0 250 550>
<SendLabel w1, w2, w3, w4, w5>
<Clickmouse Noclick>
<Key F8>
<RestoreMousePos>