I started out using keyclone initially but quickly changed to using hotkeynet.

Personally i found keyclone buggy and restrictive. Hotkeynet is much more powerful but more difficult to set up.

So it comes down to a personal decision, keyclone is good to get up and running quickly. Hotkeynet is more powerful but requires more time initially to setup, there's plenty of info here and on the wiki to help you set it up though.

HotKeyNet is free too!