I don't run any sort of visual enhancements on my alts, like unit frames, button mods, cooldown counters, any of that. As an example, my basic loadout on alts is:

Buggrabber
Ace2
Reslack
AutoProfitX
CT_Mailmod/CT_Expensehistory
DeclineDUel
eeShards
EnhTooltip
EquipCOmpare
Enhanced Flight Map
FreeRefills
Fubar (durability, money, performance, quests and a few other minor ones)
LevelSnap
MrPlow
Omen
OneBag
SimpleMountEquip
TinyTip
WIM
AutoAcceptInvite
XP_Gain_Notify