Given that we've derailed 2 threads on this topic so far, I figure we may as well have a thread actually discussing the issue than spinning off from existing threads.
First things first, I think its best to describe where we're coming from. I have 1 of each class, and I've extensively experimented with them to determine optimal output. The only roles I haven't specifically written macros for are feral druids, holy pally, ret pally, enhancement shaman, arcane mage, and prot warrior, and of those, I don't expect any to be any more complicated than what I've already done for the other classes.
The conclusion I reached through all this observation and experimentation is that the more dynamic your group gets, the more unwieldy it becomes. However, this also comes from my perspective of optimizing every class, with the ultimate goal of making every class play as close to as it would if an individual were controlling it.
Example: You can toss a fire or frost mage in to a group with the intent of gaining the +10% crit chance. This works on the level that you can get the buff fairly easily, but it becomes a good deal more complex as you dig deeper in to maximizing their potential. When classes are balanced by Blizz, they are done so with the perspective that said class is being played by one person who is capable of managing the various cool downs, DoTs, and procs. Their ideal damage is thus based on the difficulty of the rotation as it would be run by a normal player. Now, you can toss a fire mage in to a group and get your two scorches up fairly quickly, but ideal damage suggests that you should also have living bomb and be taking advantage of hot streak procs. Now you CAN spam Frostfire Bolt and keep these other spells out of rotation, but you won't be getting optimal damage.
Some may view this as a challenge, some may view it as an unnecesary overcomplication.
Expound on this situation with multiple DPS classes. If you are looking for a quick way to up your damage, macro-fiddling tends to work fairly well, and requires little initial investment. However, when you're talking 5 different classes, that investment of time and research starts stacking up. In the case of the 4 shaman groups, Fiddling with your dps macro affects all 4 characters, providing a larger buff to group DPS than you get by improving just one character.
Now in the case of everything being pre-set up and if your macros are running as efficiently as you need them, this becomes a moot point. If you're clearing content and achieving goals, optimization and external opinions be damned. If you hit a wall though, there are a larger number of potential factors to be considered in how to breach said wall if you have a multi-class group than a simple tank-4 shamans.
My position is that running a multi-class group is more difficult, and only slightly more rewarding than the simpler but largely just as effective set up of shamans. That said, when people ask for opinions on the subject, I feel it necesary to put forth both the advantages and disadvantages of the respective set ups. The answer isn't as simple as one or the other, but should be tailored to what the inquisitor's goals, aspirations, and values are.
Its not simply a matter of Synergy versus Simplicity, but how much you value either. Cross class groups gain synergy at the cost of simplicity, and core class groups do the opposite. The two aspects are not mutually exclusive, but vary depending on a number of factors.
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