We had the same problem with PiP and Keyclone with Windows 7 64. Another problem (not related to Keyclone I don't think) was that the main window would stop responding occasionally (only at really inconvenient times of course). Only ever the main window and incidentally almost always on Patchwerk! Unlike you, though, we found a huge performance increase with Windows 7 in general. However the PiP problem and the lockup problem forced us to abandon the experiment and move back to Vista 64.