Ahh... half of my post got cut off...

I'm using HotKeyNet (Freddies Program) and Keyclone. Not AHK. Sorry about the confusion... That's the last time I try to type and not check over my post before posting ...

Let's say you have two spells (Death and Decay on Character A)...

Then we'll also state that Hurricane (Druid) is on key 1 of Character B.
Going back to my previous example, we'll utilize the ~ as the trigger key.
When you press and hold ~ (to activate the mouse pass through on HKN), you can click on key 1 with either Character, and then click on the target area.
The target area is simply where you would like your spell to land.
From my experiences with both programs, HotKeyNet does not seem to be resolution dependent.
That is to state, my main character has a resolution of about 1680x1050 (I run her on the main screen), my other 4 toons are setup in the quadrants that I described earlier.

The other four toons function on a resolution of 800x600 (default resolution in keyclone w/ the maximizer).
The clicks are all passing seamlessly. So, to answer your question
To be simple say I had my death and decay button on key 1.
If using the above all I would have to do is press ~ then press 1 and right click my screen where I want the aoe?
You'd just press and hold ~ then click on your spell (key 1), and then click on your screen of where you want the spell to occur.

Cheers!