AutoHotKey can accomplish this... and it plays well with Keyclone
I use AutoHotKey to pass a mouse click into one of my WoW windows. To Illustrate this, think of this example:
MONITOR 1 -
Death Knight
MONITOR 2 -
Quadrant 1 - Shaman, Quadrant 2 - Shaman, Quadrant 3 - Shaman, Quadrant 4 - Druid
I'm using Keyclone's maximizer to achieve the above functionality. Then, with AutoHotKey, I have a script where I hold the tilde key (~), and click with the mouse on a spell w/ Monitor 1, that click is passed into any of the other 4 quadrants that I specify. Typically, I'd click on a targetted AOE with the DK (Death and Decay), then cast Hurricane with my Druid at the same time.
I've found that the response time is almost instant (we're talking maybe a 20-30 millisecond delay, almost un-noticable to the human eye) with AutoHotKey, and AHK has been about 93-98% accurate.
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