I just tried this as my first heroic. I quickly realized how bad I am at multiboxing :P

I managed to actually kill the first boss (the guy near the pit of small snakes - guess first boss depends on where you enter??). I wiped a couple of times though. The AOE got my slaves. I never bothered going to the colossus.

My current problem is my paladin tank losing aggro. I need to calm down on button smashing or something.