I can not remember much, I played LotR for about 3 months when it first came out. I two boxed a Champion and Minstrel. I got them both to 50 with maxed tradeskills. I did not know about keyclone or innerspace at the time. I did it the old school "alt-tab" way.

What i do remember is you could make very limited macros at the time. I was able to follow and keep my leader targeted. It was easy to do because if your targeting a friendly target and you cast an offensive spell, it will assist your friendly target automatically.

I chose a champ, minstrel at the time for a two easy reasons. Champs can be tanks ( OT type ) and were ( might still be ) the best AE class in the game, they had melee attacks that laid waste to tons of mobs at a time. And the minst was the primary healer. SO it was an easy choice for two boxing.
I think they added two new classes since I played, Warden ( a tank type ) and rune master ( caster ). I know nothing about those atm.