Having spent the last month or so debating on a setup, researching, and planning stuff out I'm finally at the point where I have a rough draft that is ready for a second set of eyes.
I am planning on PvE Software boxing using Hotkeynet.
My healer will be click healing.

Class Selection:
Unholy DK: AOE tank with dps capes. Buffs groups damage

Resto Shaman: Everybody needs a little shaman lovin. Strong totems, Mana Tide, Chain heal, Cleanse Spirit, Can reincarnate. (will also be my main for solo raiding)

Demo Lock: Demo seemed to have a simple rotation. Curse of Elements for more damage, as well as extra damage from the pet crits. So a little synergy. Also comes with soulstones, and summons.

Frost Mage: I know that spamming just frostbolt is tough, but I should be able to manage that complicated rotation. The pet I will keep to CD use only, as well as Mirror Image. Focus magic buffs the warlock for more pew pew. Comes with the arcane taxi, as well as mage cookies. AI is always a nice addition too.

Boomkin: MotW, Moonkin aura, Battle Rez, Chicken Dance.

Basically I was going for strong group synergy with lots of damage increasing buffs/debuffs. (Ebon Plaguebringer, WoA, Warlock Spellpower Pet buff, Moonkin Aura)

Key Setup:
----------DK----------Sham----------Lock----------Mage----------Boom
1---IT,PS,BS,SS,SS---LB,,,,,,,---Pet+DE,SB-----Frost Bolt-----WR,SF,SF
S1--------UB,---------------------CoA,Corr-----Frost Bolt-------IS,MF
C1----Bone Shield----ES Tank-------------------Spell Steal---Throns Tank

2-----Obliterate------FS,LB---------SB----------FB,FrstBlt-------MF
S2-------------------------------Soul Steal

3----Chains of Ice---Earthbind----AoE Fear------Frost Nova
S3----Mind Freeze-------ES------Race Silence------CS,Race-----Warstomp

4-----SS,Pes,BB-----Nova Tot,,,,----SoC-------------AE----------SF,MF
S4-----DnD,UB----------------------,RoF------------Blizz-----Trees,Hurri

5-----EmpW,AotD----Elem Tot,BL----Metamorph------IV+Pet,MI-----SF,Trees

Z-------IBF--------NS+Heal ToTT-----------------------------Brez,Innervate
SZ--,Fear Trink---Trem Tot,Trink--,Fear Trink----,Fear Trink--,Fear Trink

X---------------------Totems
SX----------------Grounding Totem

C----Blood Tap-------Cleanse----------------------Decurse------De-poison
SC----------------Mana Tide(com)---Buffs(ooc)-----Buffs(ooc)-----Buffs(ooc)

1 is my spammer. Shaman casts a random LB here and there. Just a little extra dps, but not enough to hurt his mana.
Shift 1 is for after the initial DK sequence on long fights. (bosses)
Ctrl 1 is for pre combat, and things needed to keep on the tank. Also trys to steal a spell.
2 is my quick damage button. Not really to be spammed on elite fights, but for normal mobs it should hurt them.
3 is my snare button. Shift 3 for interrupts.
4 is my tab target AOE key. Shift 4 is my click cast AOE. (~ will be my send mouse click key)
5 is my ohh snap here comes the pew pew.
Z is my ohh shit (any other tfc players out there? "MEDIC!") When I have an alli targeted: if dead my druid rezes them, if alive he innervates them. In combat only of course.
X is my totem button, spam it to drop all 4. SX for a grounding totem.
C is my utility button. DK blood taps for more runes, and if something unwanted. It will disappear.
SC to drop mana tide in combat, or buff ooc.

Question Time:
My biggest unknown is the moonkin. Does his synergy stack? MotW is nice and all, but I can't watch for eclipse procs, so his personal DPS won't be as high as it can be. I'm hoping his group synergy will make up for his lack of DPS.

Is a DK's ghoul useful? I think I might be a bit on the low side for DPS due to the moonkin not being able to use eclipse procs properly. If I put one talent point into that would it help makeup for the lost dps? EJ and everyone I have talked to says its a waste of a point as a tank, but I havn't talked to any multiboxers.

FTL - Am I correct in assuming I would take up 15 keys for the above stated setup? I am a debate about how to handle targeting. I would like for it to be easy to play my second team of 5x boomkins (using the boomkin from this group + 4) for PvP shenanigans. I imagine if I setup FTL on both, and then just do a page swap on the boomkin in this group it would take no effort to make the change. The other system I was thinking about was a party1 system, because when I use PiP (F1-F5) I could easily promote whatever character i switched to, to the leader. Any suggestions?

What macros would you use to handle reapplications of dots? If I am using FTL I can't use something like reset=alt to start the macro over again. So how would I restart a sequence?

Please post your comments, let me know of things that I haven't thought of, or am flat out wrong on.