FTL - makes sense for non-homogene grps?

[Ken]

In no cases is ftl ever ''required''.

It's just awesome to not have to make those 20ish macros to switch focus.

You don't need 20ish macros if you use modifiers to switch focus.
For example: "+" for set focus (with modifiers to determine which char you want) and "-" for clearfocus (of current screen's character only, so this key shouldnt be broadcasted)

*shrug* when I was using keyclone I always had one macro per PiP key so things got switched around when I switched windows.

You can use shift/ctrl/alt(and combinations of that) + a regular key for PiP switching. This would lead to 1 button click in WoW and the WoW macro would then handle the ctrl/alt/shift modifier accordingly, like this:
/clearfocus
/focus [modifier:ctrl,modifier:shift,target=Avarell] [modifier:ctrl, target=Willyam] [modifier:shift, target=Jeck] [target=Joeh]

[edit] The only drawback of this is that sometimes Keyclone makes one of these modifiers stuck in its state, even after you switched screen. That would lead to shift/ctrl/alt still being pressed(even though you dont physically press it) after switching away from that window.