I've been playing with one of these for several months, and just love it.

The only time I have to touch the keyboard is when typing in the chat window.

I do, however, still us the mouse a lot, I have a mouse with 9 or 10 buttons on it (Logitech MX Revolution) (the thumb 'wheel' has three click positions)

Between the two it is awsome, thumb on the mouse = Alt or Control or Shift, which allows the 14 buttons on the n52te to be 52 buttons.

Anyway, it has my vote.