There are a couple tricks with DKs and their cast sequencing. The are a few abilities that will get you stuck if you aren't careful. Deathcoil is one of these abilities. Since you have Rune Strike in the macro, it is possible that the DK will not have 40 RP when they get to the Death Coil step. They will sit there doing nothing. Unless you have some really good RP5, you aren't going to get to 40 RP without using runes. Blood Boil is another catchy ability. If you don't have any diseases up, then it will sit there. You also have to be careful with reset conditions. If you are downing things quickly and you reset on target, or you change targets a lot, you could find yourself waiting on rune cooldowns. While it's preferable to start a new rotation, I'd prefer to get two Blood Strikes off than wait for a frost rune so I can Icy Touch.

I would change your macro to the following:

Code:
#showtooltip
/startattack
/castsequence reset=10 Icy Touch, Plague Strike, Death Strike, Blood Strike, Blood Strike
/cast !Rune Strike
The ! tells it to only turn Rune Strike on, it does nothing if it is already on. Without the ! you will just toggle it everytime. Another thing is that this is a short rotation. You should always look at DK rotations in 20 second blocks. Since diseases last mroe than 10 seconds, its a waste to reapply them too early. Also, if you have any Death Rune talents, you need to extend teh rotation to take those into account. You were only using 1 of your Blood runes in the above rotation, btw.

Not sure on specific strats, as I haven't started instancing on my DK group, 71 but no gear. Just thought I'd chime in on the macro. I'll try and add more when I get home.

- Souca -