You cant run 3 monitors crossfire or sli. What you do is plug all 3 monitors into the card and run it. If you want to play Crysis or something just click crossfire and use your main monitor. I have the 4850x2 and its very nice. I can turn on crossfire and use two monitors. One twist though is I use one monitor in portrait mode. This puts the stop to crossfire with 2 lcd. If you dont invert your LCD you can crossfire 2. Running 3 just plug them in to the dvi's and play. Your choice to run 3 is buy two cards, buy the 4850x2 which can run 4 monitors, or buy that triple head go which I think is a waste.