yes, you can specify any layout you want using the new region editor. it doesn't work 100% the way i'd like, but you can layout any region pattern you want.

on the maximizer panel
hit reset to clear
hit the '+' to get a new region
left-click drag the region around
uncheck the snap to grid for easier movement
or you can type the position/dimension at the top to position the region directly.
left-click drag the corners to resize.

repeat for all your regions.
right-click to remove a region

left clicking on a region selects it

you can name each region, which comes in handy with commands

the new command editor will enable you to specify a particular region for each command. no more guessing.