Well, your specs look ok to me for 5 boxing, the layouts on the Keyclone page are great, i use them and have no problems at all. I started out 5 boxing on my 24" LCD with 4 PiP, but it was a bit cramped for me, so I hooked my 19" CRT up too and things are great now. I would think it might be a little cramped, but considering that for the most part, it's just to check they are with you, or a quick right click on quest givers, you might be ok.