Using this system works very well for multiple setups:

A new FTL system - utilizing /click

I have one target macro for my Shaman, Pally, Moonkin x3 group, a different macro for my Moonkin x5 group, and a different macro for my Shaman, Pally, Moonkin x2, Priest group. All I need to do to switch the system is place the correct macro into the spot referenced by all the /click. Takes about 10 seconds total to switch 5 toons to the new group composition.