Due to multiboxing I have to plaly with all my video settings on low, including my view distance. For the quest where you shoot a harpoon at 3 buildings on the other side of a river, I was stuck for a good 20 min. I couldn't tell what I was supposed to shoot at until I finally turned my view distance to max and it was clear what I was supposed to look at...

I, too, have sent my slaves off a cliff due to hopping on something that causes me to fly. It's pretty funny when that happens