for macros, check out these threads stickied in the newbie area:

[Keyclone] step-by-step wow macro setup (level 1.5)

[Keyclone] step-by-step wow macro setup (level 2.0)

if you have the /assist joe and /follow joe style macros, i would consider that level 1.0, the bare basics. level 1.5 makes it a bit more flexible, allowing you to change your lead, in the case where the original has been reduced to a pile of goo.

i would recommend level 2.0, as it removes the need to constantly hit assist after acquiring a new target. you end up making a macro for every targeted spell, which may sound like a lot of work, but you only do it once for every new targeted spell. trust me, it's 100 times better

if you have any questions, please feel free to drop me a note.