Focus on skills that don't depend on mouse movement. I'd go more for talents that improve arcane explosion, frostfire, scorch, blast wave, dragon's breath, living bomb over anything that's blizzard-based. Cone of Cold *could* be used to some degree, but I'm going arcane/fire with something like this:
http://www.worldofwarcraft.com/info/...00000000000000
5x arcane explosions..
5x living bombs..
5x pyroblasts..
5x blast waves..

Although.. PoM may be too fun to pass up.. the damage from arcane/fire for AoE and single target , without the need for mouse involvement/targeting is looking quite nice.