I'd be ok with anything, all I really want is each character to perform the best they can perform. The only other consideration besides that is money and honestly you can make so much money via dailies or any other various professions you may have on your characters, you shouldn't really consider the professions of your main character based off things like being able to DE stuff or mine nodes in instances IMO. Sure having enchanting to DE stuff is good but up until you're at 450 enchanting it won't make you very much money since you'll be using mats to level instead of vendoring the items.

But, refer to my first point anyway about how money is easy to make anyway.