Best advice ever:

Get carbonite. It has its own little minimap and will show you exactly where you need to go for each quest, right on your minimap. When I want to do my Ice crown dailies, I log in (I always log out at crusader's pinnacle cause its really close to Dalaran and the dailies), I fly to the airship, pick up every single quest on the airship (because all of them are multiboxer friendly). I then follow the colorful boxes on my minimap in an order that seems like it will require the least amount of travel, doing all the quests as I fly in a big circle, arriving back at the airship to turn everything in. Just make sure when you're ready to do the "kill 20 ymirheim vrykul" quest you land just north of ymirheim and pick up the assault by ground quest - can knock both out at the same time - then do assault by air while you're down there. I also recommend picking up the JC daily if you have a JCer cause it seems like a lot of times its to kill a vrykul - can knock that out there also.

Then, I fly to Shadow Vault, pick up the 3 quests, do them, then before turning in fly to that little place off the side of the cliff southwest of there, pick up 2 of the quests (I never do the intel document one, biggest waste of time ever), finish those, turn those 2 in and then turn the 3 in at shadow vault.

All said and done thats like 17 or 18 quests in about 1 1/2 hours. I don't bother with any other quests, the travel time isn't worth it and I'd rather be running heroics or making money some other way.

In case it hasn't been said yet: When you do the quest to light the buildings on fire with the protodrake, don't bother flying around, you can just spam #3 and light the same building on fire 8 times. For the ebon banner quest you can plant 5 banners for each kill (1 for each character), and for the gryphon rider kill quest don't bother mounting the vehicle, just fly to one of the tall towers that has a gryphon on it, kill the gryphon, and then stand on the tower killing gryphons as they fly by. I can usually get all 10 within 30-45 seconds that way.

Edit: Forgot to add - when you do the "No rest for the Wicked" quest to kill alumneth or whatever his name is - make sure you drink that concoction for the writhing mass quest before you go into his building - all the guys you have to kill in there before summoning him drop tainted essences so you will have 10 on each of your guys before you even kill him, then you just walk outside and throw them into the cauldron and you knocked 2 quests out at the same time.