My group is 1 paladin + 4 priests.

I use focus to find my main..

If my main dies, it's just one hoykey click to change to a new main...

my spells work like this:

#showtooltip
/cast [target=focustarget, exists, nodead, help] Renew()
/cast [target=focustargettarget, exists, nodead, help] Renew()
This macro first tried to heal my focuses target, then if that isnt an ally or is dead, it then heals my focus targets target. (aka it heals whoever my focuses target is beating on)
This is my generic heal button.


#showtooltip
/cast [target=focustarget, exists, nodead, harm] Smite()
Hits the focuses target with smith.

/follow focus
Follows the focus

I buff like this:

Priest 1
#showtooltip
/castsequence [target=focustarget, exists, nodead, help] reset=10 Power Word: Fortitude(),,,

Priest 2
#showtooltip
/castsequence [target=focustarget, exists, nodead, help] reset=10 ,Power Word: Fortitude(),,

Priest 3
#showtooltip
/castsequence [target=focustarget, exists, nodead, help] reset=10,,Power Word: Fortitude(),

Priest 4
#showtooltip
/castsequence [target=focustarget, exists, nodead, help] reset=10 ,,,Power Word: Fortitude()

Target Player 1, click hotkey, target player 2, hit hotkey, ect... on each hit the castsequence makes one (and only one) buff so I can quickly buff the entier group.

I use focus for everything except CC.

For CC I just use the normal target for that...
For example my Warlock group uses the numberpad:

3 rows of three keys.
7 8 9
4 5 6
1 2 3

One column per clone, top row assists the focus, middle row makes the pet attack the target (used for voidwalker offtanking) bottom row fears the target.

Numberpad 7 = /assist focus
Numberpad 4 = /petattack
Numberpad 1 = /cast Fear()

Numberpad 8 = /assist focus
Numberpad 5 = /petattack
Numberpad 2 = /cast Fear()

Numberpad 9 = /assist focus
Numberpad 6 = /petattack
Numberpad 3 = /cast Fear()

ps: I got this from someone here, don't remember who, but I love the setup. The only problem is wanding. To work arround that my wand macros actually target the focuses target, then shoot.