I started with winEQ2 and AHK back when I was playing DAoC
With Wow I started with Octopus then switched to Keyclone when it stopped being supported. I still used AHK for certain scripts
Now I exclusively use Innerspace and ISBoxer.

Some of the idiot proofing in ISBoxer is proving troublesome to me so I disable most of it (eg Jamba integration and easy FTL) and use the Wow macro functionality (love this by the way) to do the same things.