I tried that, my friend. I think it has something to do with the way Wine handles the .exe. I thought I'd be able to run Wine with a virtual desktop fixed to 1680x1050 and then run each client windowed at a lower resolution. When the second client runs, it fouls up the first client and never opens fully.

If I could force the second client into a second instance of Wine, I think it'd fix the problem. Or, something I just thought of would be to use Cedega to run the second client... assuming Cedega doesn't share any of the Wine files.

As far as a single instance of WoW is concerned, I'm getting between 30-60 fps with my Radeon x1650 card. I have the settings turned down quite a bit though, almost minimum. I'm thinking that if I had a nvidia chipset card and better drivers, I could jack the settings up more.