I run an oddly diverse group: DK Tank, Elemental Shaman, Shadow Priest, Balance Druid, Resto Druid.


I tank / dps with 9,8,7,6,5.
I heal with F6-F12, using F1-F5 to target who needs heals.
My DPS has 2 main macros, 1 /follow party1, and 2 /assist party1.
My Healer has the same macros as my DPS but another that I can bind to target a specific party member by name.
I use alt+F1-3, 5-12 for specific stuff to fire off. Such as totems, shadowform, Doomkin Form, decursing, poison removal, battle rez

Using ClickBoxer can make things really, really simple because you can just send a key directly to a wow instance and not worry about unbinding it on each system you DON'T want an action to fire off.