May I ask your system spec', and if you run the 5 windows, so that they are all visible everytime or that some of them arent? (the later would explain why the ms are so high).
My system is almost 1.5 years old, and I'm trying to make it work until I decide I'm committed enough to justify building a new machine. It's specs are:
Core 2 Duo E6750 (2.66GHz, something like that)
GeForce 8600GTS
8 GB DDR 800 (as of yesterday)

I just installed the ram (8GB from 4GB), but I haven't noticed my system using more than about 3.6 GB at a time yet. The CPU is the bottleneck, and I just overclocked it to 400MHz FSB from 333. I'm sure it helps, but both cores are still pegged at 100% load while gaming.

I'm running the windows so that I see all 5 all the time. What would be the alternative; keep them minimized while clicking? Typically they are in the first configuration (1x 1280x720, 4x 400x300) I've got a second monitor but I generally only use it when I'm reading/typing text on the secondary characters. I was thinking of trying out keyclone since it has the FPS limiting function, but it sounds like overall, it's less configurable than HKN. Do you know if I could achieve something similar using HKN? Thanks for the help Olipcs.

A couple of side notes: I got my X-keys set up now, and they're amazing! I printed out the labels like in Xzin's guide even. =P Also, I have 5 folders listed in the HKN script, but the large data files are symbolically linked to a 6th folder. If you ran 5 seperate (unlinked) WoW installations, you would create a lot more work for your PC.