I'm running in Vista with Maximizer, 1 main on main screen and 2 copies on the 2nd screen. The only time I experience the mouse moving is when I first start or close the WoW's that run with Maximiser...

I haven't used Max's options to set up the screens etc, I've edited the shortcut properties (from the desktop shortcut) there's a thread around that detailed how to do this, which I copied, I'll see if I can find it...