make sure you're using updated version of your addons (matching the wow version, for example 3.0.3 etc) as most get broken when Blizzard releases a new patch.

if the problem still persists, then i'm afraid the problem is probably between the keyboard and the chair.
Check the folder structures, make sure they are all correct. (an easy mistake is to have you addon in a double subfolder, for example "Interface>Addon>MyawesomeAddon>MyawesomeAddon>fil es" , when you should only have 1 MyaweomeAddon folder.)